Receptors for serotonin and many other neurotransmitters (a)...

Name: Problem 5, Chapter 41: Biology
Uploaded: 2021-08-07T07:15:11-08:00
Duration: 3 min 26 s
Channel: Bryan Valdivia
Description: Receptors for serotonin and many other neurotransmitters (a) are voltage-activated ion channels (b) permit influx of chloride ions, leading to depolarization (c) inhibit EPSPs (d) are ligand-gated channels (e) are passive ion channels

Receptors for serotonin and many other neurotransmitters (a) are voltage-activated ion channels (b) permit influx of chloride ions, leading to depolarization (c) inhibit EPSPs (d) are ligand-gated channels (e) are passive ion channels

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Key Concepts

Voltage?Gated Ion Channels

Voltage?gated ion channels are those that open or close in response to changes in the membrane potential. They are essential for initiating and propagating action potentials throughout neurons but operate by a mechanism distinct from that of ligand?gated channels used in neurotransmitter signaling.

Ligand?Gated Ion Channels

These are channels that open or close in response to the binding of a chemical messenger, such as a neurotransmitter. When the ligand binds, it causes a conformational change that permits ions to pass through the channel, leading to rapid changes in the post?synaptic membrane potential, which is fundamental to fast synaptic transmission.

Passive Ion Channels

Passive ion channels allow ions to travel down their electrochemical gradients without the use of metabolic energy. The direction and magnitude of the ion flow depend solely on the existing concentration and electrical gradients, making them crucial for mediating rapid changes in membrane potentials during synaptic activity.

Transcript

00:01 Okay, one of the question is talk about the serotonin receptor, okay? serotonin receptor.

00:12 Cerotonin is a neurotransmitter, okay? and the receptor for this serotonin, for this molecule, is a g protein coupled receptor.

00:22 Okay, the receptor for serotonin is going to be linked to a g protein.

00:28 Let's suppose this is a cell membrane, okay? and here we're going to have the extracellular domain of this receptor.

00:37 This g -potting couple receptors is also called a serpentine receptor or seven -pass receptor.

00:43 Like this.

00:46 Why? because it crosses the cell membrane seven times, one, two, three, four, five, six, and seven.

00:54 Seven -pass receptor or g -protein -couple receptor.

00:56 And this is going to have an intracellular domain here.

01:01 Now also here it is going to be bound to a g protein that is going to have the alpha, vita and gamma domains.

01:10 In the inactive form it means when serotonin is not bound to this molecule, this alpha domain is going to be bound to gdp.

01:17 It means it is going to be inactive.

01:19 But once serotonin binds, the gdp is going to be removed and it is going to bind gtp.

01:26 And it is going to get active, okay? it involves activation of the adenyl, cycling, okay, in the rise of amounts of cyclic amp, and activation of protein kinase a...

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