To estimate $\mu$, we need to use the formula for the estimated marginal mean:
$$\hat{\mu} = \hat{G}_0 + \hat{G}_1x_{21} + \hat{G}_2x_{22}$$
From Exercise 15.66, we know that $\hat{G}_0 = 500$, $\hat{G}_1 = 50$, $x_{21} = 2$, and $x_{22} = 3.5$. Plugging in
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