Question

Researchers in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension have compared candidate loci in humans and rats IStoll, M., et al. (2000). New Target Regions for Human Hypertension via Comparative Genomics. Genome Res. $10: 473-482$ ]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?

Name: Problem 21, Chapter 17: Essentials of Genetics
Uploaded: 2026-02-13T20:36:46-08:00
Duration: 2 min 13 s
Channel: James Kiss

   Researchers in search of loci in the human genome that are
likely to contribute to the constellation of factors leading to hypertension have compared candidate loci in humans and rats IStoll, M., et al. (2000). New Target Regions for Human Hypertension via Comparative Genomics. Genome Res. $10: 473-482$ ]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?

Essentials of Genetics

William S. Klug,… 10th Edition

Chapter 17, Problem 21

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Solved by Expert James Kiss

02/13/2026

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By comparing the genomes of humans and rats, researchers can identify common genetic regions that are likely to contribute to hypertension. This is because rats are often used as a model organism for studying human diseases, and they share many genetic Show more…

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Researchers in search of loci in the human genome that are likely to contribute to the constellation of factors leading to hypertension have compared candidate loci in humans and rats IStoll, M., et al. (2000). New Target Regions for Human Hypertension via Comparative Genomics. Genome Res. $10: 473-482$ ]. Through this research, they identified 26 chromosomal regions that they consider likely to contain hypertension genes. How can comparative genomics aid in the identification of genes responsible for such a complex human disease? The researchers state that comparisons of rat and human candidate loci to those in the mouse may help validate their studies. Why might this be so?