Question

RNA Posttranscriptional Processing Predict the likely effects of a mutation in the sequence (5')AAUAAA in a cukaryotic mRNA transcript.

Name: Problem 3, Chapter 26: Principles of Biochemistry
Uploaded: 2021-10-02T15:32:29-08:00
Duration: 1 min 51 s
Channel: Rashmi Gondi
Description: RNA Posttranscriptional Processing Predict the likely effects of a mutation in the sequence (5')AAUAAA in a cukaryotic mRNA transcript.

   RNA Posttranscriptional Processing Predict the likely effects of a mutation in the sequence (5')AAUAAA in a cukaryotic mRNA transcript.

Principles of Biochemistry

David L. Nelson,… 7th Edition

Chapter 26, Problem 3

Instant Answer

Solved by Expert Rashmi Gondi

10/02/2021

Step 1

This sequence is known as the polyadenylation signal, which is crucial for the addition of the poly(A) tail to the 3' end of the pre-mRNA molecule during RNA processing. The poly(A) tail is important for the stability of the mRNA molecule, its export from the Show more…

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RNA Posttranscriptional Processing Predict the likely effects of a mutation in the sequence (5')AAUAAA in a cukaryotic mRNA transcript.

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Key Concepts

Polyadenylation Signal

The polyadenylation signal is a specific nucleotide sequence in eukaryotic mRNA, typically AAUAAA, that directs the cleavage of the newly synthesized transcript and the subsequent addition of a poly(A) tail. This tail is crucial for mRNA stability, export from the nucleus, and translation. A mutation in this sequence can disrupt these processes, leading to improper mRNA processing.

mRNA Posttranscriptional Processing

mRNA posttranscriptional processing refers to the series of modifications that a precursor mRNA undergoes after transcription. Key steps include the addition of a 5' cap, splicing, and the addition of a poly(A) tail. These modifications are essential for the maturation, stability, and translational efficiency of mRNA; therefore, a mutation in the polyadenylation signal affects the overall process and functionality of the mRNA.

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