Sickle-cell disease is inherited as a recessive genetic...

Sickle-cell disease is inherited as a recessive genetic disorder in humans; the normal hemoglobin allele $[H)$ is dominant to the sicklecell allele (h]. For two parents of genotype Hh (carriers), construct a Punnett square to show the possible genotypes of their children.

Labs

Want to see this concept in action?

NEW

Explore this concept interactively to see how it behaves as you change inputs.

View Labs

Key Concepts

Heterozygous vs. Homozygous

Heterozygous refers to having two different alleles for a particular gene, while homozygous means having two identical alleles. This distinction is important in genetics since the combination of different or similar alleles determines whether dominant traits are expressed or a recessive trait may appear in the phenotype.

Punnett Square

A Punnett square is a visual tool used in genetics to predict the genotypic and phenotypic outcomes of a cross. It organizes the possible alleles from each parent and demonstrates all the potential combinations in their offspring, making it easier to calculate the probabilities of inheriting particular traits.

Alleles and Genotypes

Alleles are different forms of a gene, and a genotype is the combination of alleles that an individual possesses. This concept is crucial for understanding how specific traits are inherited, as each parent contributes one allele to their offspring, determining the genotype and potentially the phenotype.

Dominant and Recessive Inheritance

In dominant and recessive inheritance, a dominant allele masks the expression of a recessive allele in a heterozygous individual. For a recessive trait to be expressed in the phenotype, an individual must inherit two copies of the recessive allele, one from each parent.

Transcript

Please give Ace some feedback