Question

Some of the mutations mentioned in Problem 28 have an interesting property. They prevent the formation of the antiterminator that normally takes place when the tryptophan level is low. In one of the mutations, the AUG start codon for the $5^{\prime}$ UTR peptide has been deleted. How might this mutation prevent antitemination from taking place?

Name: Problem 29, Chapter 16: Genetics: A Conceptual Approach
Uploaded: 2021-12-18T21:50:59-08:00
Duration: 42 s
Channel: Rabeya Zahid
Description: Some of the mutations mentioned in Problem 28 have an interesting property. They prevent the formation of the antiterminator that normally takes place when the tryptophan level is low. In one of the mutations, the AUG start codon for the 5^' UTR peptide has been deleted. How might this mutation prevent antitemination from taking place?

   Some of the mutations mentioned in Problem 28 have an interesting property. They prevent the formation of the antiterminator that normally takes place when the tryptophan level is low. In one of the mutations, the AUG start codon for the $5^{\prime}$ UTR peptide has been deleted. How might this mutation prevent antitemination from taking place?

Genetics: A Conceptual Approach

Benjamin Pierce 5th Edition

Chapter 16, Problem 29

Instant Answer

Solved by Expert Rabeya Zahid

12/18/2021

Step 1

It signals the ribosome to start synthesizing the protein from that point. In the case of the $5^{\prime}$ UTR peptide, the AUG start codon initiates the translation of the leader peptide. Show more…

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Some of the mutations mentioned in Problem 28 have an interesting property. They prevent the formation of the antiterminator that normally takes place when the tryptophan level is low. In one of the mutations, the AUG start codon for the $5^{\prime}$ UTR peptide has been deleted. How might this mutation prevent antitemination from taking place?

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Key Concepts

Attenuation

Attenuation is a regulatory mechanism in gene expression where the formation of alternative RNA secondary structures in a leader region determines whether transcription continues or terminates. In operons, such as the tryptophan operon, the balance between antiterminator and terminator structures is influenced by the rate of translation of a leader peptide, allowing the cell to respond to amino acid levels.

Leader Peptide Translation

The translation of the leader peptide, initiated at the AUG codon, is critical in modulating mRNA secondary structures. When the leader peptide is translated, the ribosome’s movement along the mRNA affects the formation of a transcriptional antiterminator structure. A mutation that deletes the AUG codon disrupts this translation process, preventing the necessary ribosome activity, which in turn impairs the formation of the antiterminator and leads to premature transcription termination.

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