Suppose a drug were added to mitochondria that allowed...

Name: Problem 16, Chapter 9: Biological Science
Uploaded: 2020-06-10T00:18:19-08:00
Duration: 1 min 53 s
Channel: Mariana Roldan
Description: Suppose a drug were added to mitochondria that allowed protons to freely pass through the inner membrane. Which of the following mitochondrial activities would most likely be inhibited? a. the citric acid cycle b. oxidative phosphorylation c. substrate-level phosphorylation d. the electron transport chain

Suppose a drug were added to mitochondria that allowed protons to freely pass through the inner membrane. Which of the following mitochondrial activities would most likely be inhibited? a. the citric acid cycle b. oxidative phosphorylation c. substrate-level phosphorylation d. the electron transport chain

Suppose a drug were added to mitochondria that allowed protons to freely pass through the inner membrane. Which of the following mitochondrial activities would most likely be inhibited?
a. the citric acid cycle
b. oxidative phosphorylation
c. substrate-level phosphorylation
d. the electron transport chain

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Key Concepts

Uncoupling

Uncoupling refers to the process where the proton gradient is dissipated or bypassed, often by substances that allow protons to leak across the inner mitochondrial membrane. This decoupling of the proton gradient from ATP synthesis leads to reduced production of ATP, as the energy stored in the gradient is released as heat instead.

Oxidative Phosphorylation

Oxidative phosphorylation is the metabolic pathway that uses energy released by electrons passing through the electron transport chain to create a proton gradient across the inner mitochondrial membrane. The resulting proton motive force is then harnessed by ATP synthase to produce ATP. Disruption of the proton gradient directly impairs this process.

Chemiosmosis

Chemiosmosis is the mechanism by which energy stored in the proton gradient is converted into chemical energy in the form of ATP. Protons flowing back into the mitochondrial matrix through ATP synthase drive the phosphorylation of ADP to ATP, linking the electron transport chain to ATP synthesis.

Proton Gradient

A proton gradient is the difference in proton concentration across the inner mitochondrial membrane, which creates an electrochemical potential. This gradient is essential for driving ATP synthesis, as it stores energy that is used by ATP synthase during the process of ATP production.

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