Question

Suppose that a mutation occurs in the middle of a large intron of a gene encoding a protein. What would be the most likely effect of the mutation on the amino acid sequence of that protein? Explain your answer.

Name: Problem 30, Chapter 14: Genetics: A Conceptual Approach
Uploaded: 2020-07-11T20:05:15-08:00
Duration: 2 min 30 s
Channel: Shiksha Dutta
Description: Suppose that a mutation occurs in the middle of a large intron of a gene encoding a protein. What would be the most likely effect of the mutation on the amino acid sequence of that protein? Explain your answer.

   Suppose that a mutation occurs in the middle of a large intron of a gene encoding a protein. What would be the most likely effect of the mutation on the amino acid sequence of that protein? Explain your answer.

Genetics: A Conceptual Approach

Benjamin Pierce 6th Edition

Chapter 14, Problem 30

Instant Answer

Solved by Expert Shiksha Dutta

07/11/2020

Step 1

In the context of genetics, an intron is a segment of DNA that is transcribed into RNA but is removed during the process of RNA splicing, which occurs before the RNA is translated into a protein. Show more…

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Suppose that a mutation occurs in the middle of a large intron of a gene encoding a protein. What would be the most likely effect of the mutation on the amino acid sequence of that protein? Explain your answer.

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Key Concepts

Introns

Introns are non-coding regions within a gene that are transcribed into RNA but then removed during the splicing process before translation occurs. Because they do not encode parts of the final protein, mutations occurring in introns typically do not alter the amino acid sequence of the protein.

RNA Splicing

RNA splicing is the molecular process that removes introns from the pre-messenger RNA and joins exons together to form the mature mRNA. The process relies on specific splicing signals at the boundaries of introns; mutations that do not affect these signals, particularly those in the middle of an intron, are unlikely to impact the splicing outcome and therefore have little to no effect on the protein’s amino acid sequence.

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