Question
The amino acid phenylalanine has $\mathrm{pK}_{\mathrm{a}}=1.83$, and tryptophan has $\mathrm{p} K_{\mathrm{a}}=$ 2.83. Which is the stronger acid?
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The $\mathrm{p} K_{\mathrm{a}}$ value is a measure of the strength of an acid in solution. It is defined as the negative logarithm (base 10) of the acid dissociation constant ($K_a$) of a solution. Show more…
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The amino acid phenylalanine has $\mathrm{p} K_{\mathrm{a}}=1.83,$ and tryptophan has $\mathrm{p} K_{\mathrm{a}}=2.83 .$ Which is the stronger acid?
The amino acid phenylalanine has a pKa of 1.83 whereas tryptophan has a pKa of 2.83. Explain why phenylalanine is the stronger acid. Hint: Consider the charge in water at pH 7.4. (4 points) phenylalanine tryptophan Circle the most acidic proton in the chemical structures below (2 points each).
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