Question

The drug cidofovir is approved by the Federal Drug Administration (FDA) for the treatment of certain viral infections of the eye in patients with compromised immune systems. It is distributed in vials containing 375 mg of the drug dissolved in 5 mL of water. The manufacturer specifies that the drug should be kept at room temperature ( $68^{\circ} \mathrm{F}-77^{\circ} \mathrm{F}$ ). The vial contents are first diluted with saline and then administered intravenously with a recommended dosage of 5 mg cidofovir per kilogram of body weight. (a) Convert cidofovir's recommended storage-temperature range to the Celsius scale. (b) If the fluid in a single vial of cidofovir has a volume of 5.00 mL and a mass of 5.89 g , what is the density of the fluid, in $\mathrm{g} / \mathrm{mL}$, to the appropriate number of significant figures? (c) Convert the density in part (b) to $\mathrm{g} / \mathrm{L}$ and to $\mathrm{kg} / \mathrm{m}^3$. (d) What mass of cidofovir should be administered to a $185-\mathrm{lb}$ man? 

   The drug cidofovir is approved by the Federal Drug Administration (FDA) for the treatment of certain viral infections of the eye in patients with compromised immune systems. It is distributed in vials containing 375 mg of the drug dissolved in 5 mL of water. The manufacturer specifies that the drug should be kept at room temperature ( $68^{\circ} \mathrm{F}-77^{\circ} \mathrm{F}$ ). The vial contents are first diluted with saline and then administered intravenously with a recommended dosage of 5 mg cidofovir per kilogram of body weight. (a) Convert cidofovir's recommended storage-temperature range to the Celsius scale. (b) If the fluid in a single vial of cidofovir has a volume of 5.00 mL and a mass of 5.89 g , what is the density of the fluid, in $\mathrm{g} / \mathrm{mL}$, to the appropriate number of significant figures? (c) Convert the density in part (b) to $\mathrm{g} / \mathrm{L}$ and to $\mathrm{kg} / \mathrm{m}^3$. (d) What mass of cidofovir should be administered to a $185-\mathrm{lb}$ man?
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Chemistry. Atoms First
Chemistry. Atoms First
Julia Burdge, Jason… 5th Edition
Chapter 1, Problem 115 ↓
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The drug cidofovir is approved by the Federal Drug Administration (FDA) for the treatment of certain viral infections of the eye in patients with compromised immune systems. It is distributed in vials containing 375 mg of the drug dissolved in 5 mL of water. The manufacturer specifies that the drug should be kept at room temperature ( $68^{\circ} \mathrm{F}-77^{\circ} \mathrm{F}$ ). The vial contents are first diluted with saline and then administered intravenously with a recommended dosage of 5 mg cidofovir per kilogram of body weight. (a) Convert cidofovir's recommended storage-temperature range to the Celsius scale. (b) If the fluid in a single vial of cidofovir has a volume of 5.00 mL and a mass of 5.89 g , what is the density of the fluid, in $\mathrm{g} / \mathrm{mL}$, to the appropriate number of significant figures? (c) Convert the density in part (b) to $\mathrm{g} / \mathrm{L}$ and to $\mathrm{kg} / \mathrm{m}^3$. (d) What mass of cidofovir should be administered to a $185-\mathrm{lb}$ man?
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Transcript

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00:02 I never know how to pronounce these drugs.
00:04 Cytophobia is approved by fda for treatment of certain viral infections in the eye.
00:09 It is distributed in vials containing 375 milligrams of the drug dissolved in 5 mil liters of water.
00:27 It should be kept at room temperature 68 to 77 degrees fahrenheit.
00:34 The vial contents are then diluted with saline and administered with the recommended dosage of 5 milligrams per kilogram of body weight.
01:04 Okay, convert the recommended dosage storage to celsius.
01:25 So c degrees.
01:27 See if i can fit this on one line, so i can put this all in one paper here.
01:33 Our c degrees is equal to 5 over 9 times f minus 32.
01:42 So my first, my 68, will be 5 over 9, 68 minus 32.
01:50 My second will be 5 over 9 times 77 minus 32.
01:56 Grabbing my calculator, this one will be 20, and i'm going to go 20 point degrees c, or, yep, degrees c, and 25 degrees c.
02:22 B.
02:25 What does b ask me to do? if the fluid in a single vial has a volume of 5 milliliters, and it has a mass, of 5 .89 grams.
02:44 What is the density to the correct number of sig figs? and that'll be 5 .89 grams divided by 5 .00 milliliters equals 1 .1.
03:00 Let me do this.
03:06 1 .178.
03:11 So it'll be 1 .18 grams per milliliter to the correct number of sik figs.
03:22 Okay.
03:23 Convert this to grams per liters and kilograms per meter cubed.
03:37 Convert d to g over l and kilograms per meter cubed.
03:50 The g over l is easy.
03:51 Let's do this first.
03:52 1 .18 grams per milliliter times there's 1 ,000 milliliters per liter would be 1 .18 times 10 to the 3rd grams per liter.
04:22 And then for my kilograms per meter cubed.
04:35 Let's go...
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