The following is a segment of the template strand of human...

Name: Problem 87, Chapter 17: Chemistry: An Introduction to General, Organic, and Biological Chemistry
Uploaded: 2021-05-25T14:47:58-08:00
Duration: 8 min 23 s
Channel: Danielle Ashley
Description: The following is a segment of the template strand of human BRCAI gene: TGG AAT TAT CTG CTC TTC GCG a. Write the corresponding mRNA segment. b. Write the three-letter and one-letter abbreviations for the corresponding peptide segment. c. If there is a point mutation in the fourth nucleotide triplet and A replaces G, what is the change, if any, in the amino acid sequence?

The following is a segment of the template strand of human BRCAI gene: TGG AAT TAT CTG CTC TTC GCG a. Write the corresponding mRNA segment. b. Write the three-letter and one-letter abbreviations for the corresponding peptide segment. c. If there is a point mutation in the fourth nucleotide triplet and A replaces G, what is the change, if any, in the amino acid sequence?

The following is a segment of the

template strand of human BRCAI gene:
TGG AAT TAT CTG CTC TTC GCG
a. Write the corresponding mRNA

segment.
b. Write the three-letter and one-letter

abbreviations for the corresponding

peptide segment.
c. If there is a point mutation in the fourth

nucleotide triplet and A replaces G, what is

the change, if any, in the amino acid

sequence?

Key Concepts

Codons

Codons are sequences of three nucleotides in mRNA that dictate the addition of specific amino acids during protein synthesis. Each codon is recognized by tRNA carrying the corresponding amino acid, making codons the key units of the genetic code. These are essential in translating the nucleotide sequence into the structure of proteins.

Point Mutations

A point mutation refers to a single nucleotide change in the DNA sequence. This mutation can lead to a change in the mRNA and potentially alter the encoded amino acid, which might result in a missense (amino acid substitution) or silent (no change in amino acid) mutation. Understanding point mutations is critical for analyzing how small genetic alterations can impact protein function and lead to various genetic disorders.

DNA Transcription

DNA transcription is the process by which a DNA sequence is copied into messenger RNA (mRNA). This involves using the template strand of DNA, where bases pair such that adenine pairs with uracil (in RNA) and cytosine pairs with guanine. This concept is fundamental for understanding how the genetic code is transferred from DNA to mRNA, serving as the first step in gene expression.

RNA Translation

RNA translation is the process where the sequence of nucleotides in mRNA is read in sets of three bases (codons) to synthesize a polypeptide. Each codon corresponds to a specific amino acid or a stop signal, thus determining the amino acid sequence of a protein. This concept connects the information in nucleic acids to functional proteins.

Transcript

0:00 There's students.

00:01 Today we're going to be answering this question in regards to the chapter on nucleic acid and protein synthesis.

00:08 And for this, we're going to be focusing on the section on viruses.

00:15 And for this, they want to know, they want you to write the corresponding mrna sequence.

00:23 They also want you to write a three letter and one letter abbreviation.

00:30 For the corresponding peptide segment.

00:34 And they also have an interesting question, wondering if there is a point of mutation in the fourth nucleotide triplate.

00:48 And you have it where a replaces a g, which is why the g is a different color.

00:56 What is the change, if any, in the amino acid sequence? you could pause the video, drop down your answer, and look over this shortly.

01:10 Okay, so what would happen? so to do the mrna, we have to basically set up a corresponding for the new strand.

01:21 So for that to work, it's like just remember that a is equal to t and c is equal to g.

01:36 Just some little quickies reminders.

01:39 So for our t we get a and g we get a c and let's see we get another c and then we get two t and an a and and then all the rest.

01:55 Yeah the rest you just do a little once you get the hang of it it's just it's just easy as one two three so okay so now we got that set we're going to now have a set up or we're going to answer for part a where we got the new strand.

02:22 Now we're going to get set up for our a where we're going to have a corresponding mrna sequence.

02:30 So for that when it comes to rna, what does an rna have? it does not have a t.

02:39 So instead of t, you end up using, oops.

02:46 Instead of a t, you would end up, go away t, i don't know what t came back.

02:53 Instead of using t, you use a u.

02:57 So let's set up.

03:00 So for the corresponding mra, you would get t a t.

03:05 But see, i'm almost, for the my own rule, you, g, g, and then this becomes an a -a -u...

Please give Ace some feedback