The following reaction accounts for the synthesis of...

Key Concepts

Coupled Reactions

This concept involves linking a reversible biochemical reaction to another energetically favorable reaction in order to drive the overall process in a specific direction. In many cellular processes, a reaction that might otherwise reach equilibrium is made to proceed irreversibly by coupling it to a reaction with a large negative free energy change.

Pyrophosphate Hydrolysis

In the synthesis of UDP-glucose, the formation of pyrophosphate (PPi) is coupled to its rapid hydrolysis by pyrophosphatase. This hydrolysis releases energy and effectively pulls the reaction forward by removing PPi, thereby preventing the reverse reaction and making the overall process irreversible in vivo.

Transcript

00:01 Students, we're going to be discussing about the synthesis of udp glucose in regards to a chapter on glycogen metabolism.

00:14 So a bit about upt glucose synthesis, just basically show the rundown of what happens when it comes down to the conversion in exchange.

00:30 They brought up explaining that how their reaction is readily reversible, but somehow when it comes to fivo, is not able to referce it.

00:45 And why is that? well, if you guys saw the chapter when it comes down to the conversions that comes up when it comes to how is stored when you when it synthesized from glucose 6 phosphate and how much conversions you need to get for the udp to actually get glucose n plus 1.

01:22 It's so much conversion where glucose 6 phosphate has to convert to glucose 1 phosphate and how glucose 1 phosphate needs you.

01:32 Utp to make udp glucose and, you know, how you just need so much conversion with the the ppi with water to get two inorganic phosphates.

01:51 And then it's just so much conversions going on is so much that for the fivo, the upd u p i mean udp on glucose is not set up like how um where the like how you see for the for how the the the fuck it's not set up like how the phosphonal groups when it's attached to the when it is attached to one of the um the phosphonal um multiple multiple multiple i'm sorry i mispronounce word.

02:39 But one of the phosphonal groups have the fifo can be able to refer to that because, again, all the needs of is a phosphonal group to come in and switch with a substrate.

02:54 And then another one just comes back and just is able to fix it...

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