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The four core histones are relatively small proteins with a very high proportion of positively charged amino acids; the positive charge helps the histones bind tightly to DNA, regardless of its nucleotide sequence.
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Histones are proteins found in eukaryotic cell nuclei, tightly bound to DNA, which has many phosphate groups. The pI of histones is very high, about $10.8 .$ What amino acid residues must be present in relatively large numbers in histones? In what way do these residues contribute to the strong binding of histones to DNA?
Histones are proteins that control gene function by attaching through salt links to exterior regions of DNA. Name an amino acid whose side chain is often found on the exterior of histones.
What groups are found on the exterior of the DNA double helix? In the nucleus, DNA strands are wrapped around proteins called histones. Would you expect histones to be neutral, positively charged, or negatively charged? Based on your answer, which amino acids do you expect to be abundant in histones and why?
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