00:01
So we are going to be sketching a model that explains how a microtubule can shorten and generate force, yet remain attached to its chromosome.
00:14
So it is still not certain what drives the pullward movement of chromosomes during anaphase.
00:22
In principle, two possible models could explain it.
00:27
I'm going to be drawing the favored model, but in the disfavored model, microtubial motor proteins associated with the kinetic core dashed toward the minus end of the de -plomerizing microtubule drawing the chromosome toward the pull.
00:42
Although this model is appealingly simple, there is little evidence that motor proteins are required for chromosome movement during anapase.
00:50
Instead, current experimental evidence greatly supports this model that i'll be drawing out.
01:02
In this model, microtubial binding proteins will drive the chromosome movement.
01:24
So this is going to be the direction of chromosome movement...