00:01
So today we are going to discuss problem number there are we eight and chapter number 13 right and it's about the viruses includes their special fusion protein rather than making a use of a cell just as in right so we are going to discuss on this so you know the all cell membrane fusion requires special protein are tightly regulated to ensure that only appropriate membranes fuse.
00:48
So the controls are crucial for maintaining both the identity of cells and the individuality of each type of, you know, intracellular compartments.
00:58
So the membrane fusion catalyzed by viral fusion proteins are the best understood, right? so these proteins have a crucial role, you know, in the same.
01:10
Permitting the entry of enveloped viruses so you know into the cell that they infect right for example the virus such as the human immune deficiency virus which is you know hiv which causes aids and bind to cell surface and receptors and then fuse with the plasma membrane of the target cell so this fusion event allows the viral nucleic acid inside the nucleocapsid.
01:52
Right.
01:53
So, you know, to enter the cytosol, where it replicates other viruses, such as the influenza virus, deliver to first enter the cell bioreceptor -mediated endocytrosis and then deliver to, you know, endosomes.
02:10
So the low ph in endosomes activates fusion protein in the viral involuntary.
02:16
That catalyzes the fusion of the viral and the endosomal membranes releasing the viral nucleic acid into the cytosote...
