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Key Concepts

Cadherins

Cadherins are calcium-dependent adhesion molecules that mediate homophilic interactions between cells, playing a crucial role in maintaining tissue structure, enabling coherent cell layers, and facilitating cell signaling that governs tissue morphogenesis.

Integrins

Integrins are transmembrane receptors that mediate cell adhesion to the extracellular matrix. They link the extracellular environment to the intracellular cytoskeleton, participating in bidirectional signaling essential for cell migration, proliferation, and survival.

Cell Adhesion

Cell adhesion is a fundamental biological process where cells connect with one another and with the extracellular matrix. This process is critical for maintaining tissue architecture, ensuring structural integrity, and enabling coordinated cellular functions during development and wound healing.

Signal Transduction

Both cadherins and integrins are pivotal in signal transduction pathways. They not only hold cells together but also send signals that regulate cellular responses such as differentiation, motility, and survival. Disruption in their function can therefore impair normal cellular communication and tissue homeostasis.

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