00:01
The evolutionary theory of aging suggests that senescence aging is a product of natural selection, just like other features of life history, right? so it's saying that it is under the control of natural selection.
00:18
And it's not simply a matter of the length of telomeres or something like that.
00:22
And there really are two mechanisms by which it can happen.
00:26
One is through late acting.
00:28
So that's late acting deleterious mutations.
00:44
Deleterious means bad, right? so late acting deleterious mutation is a mutation that turns on late in the life of an organism and of course, it either kills it or speeds it towards death.
00:59
So late acting deleterious mutations.
01:03
And then two, antagonistic pliotropy.
01:08
So in antagonistic pliotropy, you have a mutation that has an early beneficial effect...