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What roles do SSBs play in DNA replication?
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SSBs, or single-strand binding proteins, are proteins that bind to single-stranded DNA during the process of DNA replication. Show more…
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92. If Single-Stranded Binding protein (SSB) is not present during DNA replication, what would you expect to see? a) The replisome complex would not assemble on the oriC region. b) The DNA cannot bend, so hydrogen bonds in the 13-mer region of oriC remain intact. c) Helicase activity is inhibited, so DNA strands cannot be separated. d) SSB carries the helicase protein to the open region of DNA, so hydrolysis and strand separation will not occur. e) SSB prevents reannealing of the separated strands, so strands would quickly reanneal and DNA replication cannot proceed. 93. What is required for DNA polymerase to initiate DNA strand synthesis? a) a short DNA primer synthesized by the enzyme primase b) a short RNA primer synthesized by the enzyme primase c) ATP and a short DNA primer synthesized by the enzyme topoisomerase d) ATP and a short RNA primer synthesized by the enzyme topoisomerase e) DNA polymerase initiates DNA strand synthesis without requiring any additional enzymes. 94. DNA helicase inhibitors are well studied as potential drug targets. What would you expect to see if DNA helicase activity is inhibited? a) The replisome complex would not assemble on the oriC region. b) The DNA cannot bend, so hydrogen bonds in the 13-mer region of oriC remain intact. c) Helicase catalyzes ATP hydrolysis and DNA strands separation, so the helix cannot be unwound and strands will not separate. d) Helicase carries the SSB protein to the open region of DNA, so hydrolysis and strand separation will not occur. e) Helicase prevents reannealing of the separated strands, so strands would quickly reanneal and DNA replication cannot proceed. 95. What is one difference between DNA replication in bacteria versus eukaryotes? a) Eukaryotic chromosomes are replicated bi-directionally, while bacterial chromosomes are replicated in one direction. b) Eukaryotic chromosomes have many origins of replication and replicate bi-directionally, while bacteria have only one origin of replication and replicate uni-directionally. c) Bacterial chromosomes are replicated bi-directionally, while eukaryotic chromosomes are replicated in one direction. d) Eukaryotic chromosomes have many origins of replication, while bacteria have only one origin of replication. e) The process is identical in bacterial and eukaryotic DNA replication.
What is the role of single-stranded binding protein in DNA replication?
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