00:01
So now that we've covered a little bit about what epigenetics is, and again, it's the difference in the structure around dna and the proteins that coil it up to make chromatin.
00:12
It's the changes in there instead of the changes within the specific dna sequence of the base sequence.
00:19
So we're going to talk about three specific mechanisms that mainly shape epigenetic states and change them.
00:26
The first is the modification of histones.
00:30
So histone modification.
00:34
Again, histones are the large proteins made up of a bunch of different subunits that chromatin coils around.
00:46
And these kind of like so little circles like this, and then dnas kind of come in and wrap around like this.
00:56
And this is going to be tightly compacted until you get something that looks like a chromosome.
01:02
So this is the interactions with the dna itself because the histones have to be able to fit around the dna.
01:10
So different modifications of molecules around these affect how loosely the dna is fitting or how tightly.
01:17
The second is dna methylation changes...