00:01
Okay, i'm going to answer this question is talk about the role of chloride in the voltage of a cell, of a neuron, okay, in this case.
00:09
Remember that if this is the post -synaptic neuron, or let's graphic like this.
00:17
If this is the post -synactic neuron, okay? normally the voltage of this cell is electronegative, okay? like about minus seven mild millivoles, for example.
00:28
Okay.
00:30
And remember that this is in contrast with the extracellular that has a voltage of like a more positive voltage, okay? it says, the question says, when an inhibitory neurotransmitters such a, such a gava, it opens chloride channels in the plasma membrane of a post -synapting neuron.
00:47
Why does this make harder for the excitatory neurotransmitter to excite a neuron? well, in general, okay, if this is a chloride transporter and this is the binding for gaba, okay? once gaba binds to this receptor, this channel is going to open and it is going to allow the movement of chloride ions here.
01:10
And remember that chloride ions are negatively charged.
01:14
So even when the concentrations of chloride in the extracellular are like higher than the concentrations of chloride in the intracellular, okay, it means that the chloral concentrations here in the extracellular are much higher...