Question

Which of the following is a correct statement describing the induced-fit model of enzyme action? Substrates fit into the active site: (a) because both are exactly the same size and shape. (b) by changing their size and shape to match those of the active site. (c) by changing the size and shape of the active site upon binding.

Name: Problem 23, Chapter 22: Introduction to General, Organic and Biochemistry
Uploaded: 2020-07-11T15:42:47-08:00
Duration: 56 s
Channel: Simon Sauvageau
Description: Which of the following is a correct statement describing the induced-fit model of enzyme action? Substrates fit into the active site: (a) because both are exactly the same size and shape. (b) by changing their size and shape to match those of the active site. (c) by changing the size and shape of the active site upon binding.

   Which of the following is a correct statement describing the induced-fit model of enzyme action? Substrates fit into the active site:
(a) because both are exactly the same size and shape.
(b) by changing their size and shape to match those of the active site. 
(c) by changing the size and shape of the active site upon binding.

Introduction to General, Organic and Biochemistry

Frederick A.… 12th Edition

Chapter 22, Problem 23

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Solved by Expert Simon Sauvageau

07/11/2020

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Instead, it changes its shape and size to accommodate the substrate once it is bound. Show more…

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Which of the following is a correct statement describing the induced-fit model of enzyme action? Substrates fit into the active site: (a) because both are exactly the same size and shape. (b) by changing their size and shape to match those of the active site. (c) by changing the size and shape of the active site upon binding.

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Key Concepts

Conformational Change

Conformational change is the process by which the enzyme undergoes structural rearrangement upon substrate interaction. This change is essential for aligning the catalytic residues properly and optimizing the molecular interactions required for enzyme catalysis.

Induced-Fit Model

The induced-fit model describes how enzyme active sites are flexible and change shape in response to substrate binding. This conformational change results in a more precise enzyme-substrate fit, enhancing the enzyme's ability to catalyze the chemical reaction.

Active Site Flexibility

Active site flexibility refers to the ability of the enzyme's binding region to adapt structurally when a substrate binds. This flexibility is crucial because it allows the enzyme to more effectively stabilize the transition state and facilitate the reaction.

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