00:03
Suppose we have an amine versus an amide, and we want to compare their pqas, and why their pqas are different.
00:11
Well, an amine has a pca range, pcaa of around 33 to 35, and this is highly basic.
00:27
In fact, amines are considered as the organic bases, because they are basically the basis of organic chemistry.
00:37
And amides, however, are pretty acidic.
00:40
They have a pca range of about 14 to 16.
00:47
And the reason behind this is, well, in acids, right, the most defining characteristic is how willing a molecule is to give up its most acidic hydrogen.
01:01
And if we were to talk about a carboxylic acid, say acetic acid, this hydrogen would be our most acidic acid.
01:10
And the pca would be a measure of how willing this molecule is to give up that hydrogen.
01:18
And when we're talking about amides, well, the amide hydrogens right here, those are acidic hydrogens.
01:28
And why is that? well, it has to do with electronegativity and resonance.
01:35
So suppose we got rid of one of those hydrogens...