00:02
Why is so much effort being poured into developing methods to determine the genome of an entire person? well, let's look at a hypothetical oversimplified example, as always.
00:21
So suppose that we have samples of healthy alleles, and noted in green here are normal variations.
00:33
And we also have dysfunctional alleles, three samples shown at the bottom.
00:44
And those dysfunctional alleles show the normal variations, but they also show additional variations that are consistent throughout.
00:53
So we would consider this a genetic mutation that is probably contributing to the dysfunction of these alleles.
01:03
So now suppose that we have a patient that comes in and gets his or her genome sequenced.
01:12
And for this particular allele, we find these variations from the norm, from the general population, which shouldn't be a alarm bell because they are normally there.
01:23
But this patient also has this mutation, which is generally found in the dysfunctional allele as well...