00:02
This question asks, why is it more likely that insertions or deletions will be more detrimental to a cell than point mutations? well, it all comes down to the fact that there is a position in these amino acid sequences that are based on the codon nucleotide base sequences that is called the wiggle position.
00:26
And that is, as you can see, in, for example, let's take arginine right here, we see that the final or the third nucleotide base there is going to not matter at all.
00:42
Because as long as we have the first two nucleotide bases as c and g, it doesn't matter if the final nucleotide base is a u, a c, and a, or a g.
00:52
So we call that the wiggle position.
01:00
And that basically means that there is some room for error there.
01:03
So in terms of likelihood, since the question is asking about likelihood and chance, we know that it is basically a 33 % chance that if our point mutation occurs in the wiggle position, then it will have no effect on the outcome of the immune.
01:25
Acid sequence...