The plasma membrane of all cells is a bilayer (two layers of phospholipids); the glycerol heads of the phospholipids are hydrophilic, which means water-loving, and face the outside aqueous (water-based) extracellular fluid or the inside cytoplasm, and the fatty acid tails are hydrophobic, which means that they are water-fearing, and stay on the inside of the bilayer, away from water.