3) B) Given Table 13-5 below for concentrations of relevant metabolites in rat myocytes,
would the actual AG for the PCr reaction above in rat myocytes be more or less
favorable compared to $\Delta G^{\circ}$ at standard conditions, or stay the same? You do not
need to completely calculate the actual $\Delta G$, but do explain the mathematical reasoning
behind your answer. The concentration of free creatine (unphosphorylated) in these
myocytes is 0.5 mM.
TABLE 13-5 Adenine Nucleotide, Inorganic Phosphate, and
Phosphocreatine Concentrations in Some Cells
Concentration (mM)*
ATP
ADPt
AMP
Pi
PCr
Rat hepatocyte
3.38
1.32
0.29
4.8
0
Rat myocyte
8.05
0.93
0.04
8.05
28
Rat neuron
2.59
0.73
0.06
2.72
4.7
Human erythrocyte
2.25
0.25
0.02
1.65
0
E. coli cell
7.90
1.04
0.82
7.9
0