1. Define myeloproliferative neoplasms (MPNs).
2. Define chronic myeloid leukemia (CML) and describe the cell lines involved, the
clinical phases, and the expected clinical manifestations, key peripheral blood and
bone marrow findings, and diagnostic criteria applicable to each stage.
3. Briefly Discuss the cytogenetics, molecular genetics, and molecular
pathophysiology of CML and relate it to treatment approaches, monitoring minimal
residual disease, and mechanisms of drug resistance.
4. Define polycythemia vera (PV) and describe the cell lines involved, clinical
manifestations, key peripheral blood and bone marrow findings, and the diagnostic
criteria.
5. Describe the mutations that occur in PMF and relate them to disease progression
and current therapy.
