An exergonic reaction means that the substrate(s)/reactant(s) have a (higher/lower)
free energy compared to the
product(s). The activation energy, which is the free energy difference between
substrate and (product/transition state)
, is (decreased/increased)
in the presence of an enzyme. As an enzyme binds its substrate, it forms a(n) (lock
and key/induced fit)
, straining
substrate bonds and forming interactions that (require/release)
energy. An enzyme (can/cannot)
catalyze a reaction that is endergonic.