The oxidation of low-density lipoprotein (LDL) leads to oxidized LDL (oxLDL)
formation. Macrophages express various scavenger receptors, such as CD36,
SR-A, and LOX-1, which bind to oxLDL and promote the formation of foam cells.
In a research laboratory, you have isolated macrophages from different strains of
mice and added oxLDL to the cultured macrophages. After incubating with
oxLDL, the macrophages were stained with Nile Red, which binds to cholesterol
esters in oxLDL, allowing fluorescent imaging to identify foam cells. Based on
this setup, what predictions would you make regarding the levels of foam cell
formation if you used macrophages from the following mouse strains? Use a
scale of 1 to 10, where 1 indicates minimal foam cell formation, and 10
represents the highest levels of foam cells.
CD36-/-, SRA+/+, LOX-1+/+
CD36-/-, SRA-/-, LOX-1+/+
CD36-/-, SRA+/+, LOX-1-/-
CD36+/-, SRA+/-, LOX-1+/-
CD36-/-, SRA-/-
, LOX-1-/-
CD36+/+, SRA+/+, LOX-1+/+