HIV Origins SIV, Modes of transmission, First signs in America, Definitions of
HIV/AIDS, AIDS deniers, Evidence for HIV as cause of AIDS, Species jump, Spread in
Humans
Biology Overall structure, definition of a retrovirus, Lifecycle, Reverse Transcriptase,
CD4+ helper T cells, R4/R5 tropism, HIV envelop proteins gp120 and gp41, How HIV
kills infected cells
Testing Who to test, ART experienced/naive, window period. Rapid Elisa test (antibody
test), Rapid antigen test, Western Blot confirmatory test, CD4 counts/viral load
Treatment Types/ classes of ART, HAART, life expectancy, Berlin Patient (plus more)
āfunctional cureā, Atripla, PreP, MTCT success, Entry inhibitors, capsid assembly
inhibitors, heavily experienced ART
AIDS in America At-risk populations Black MSM, Young, Poor, "Southernā, āreasonsā
Prep availability, NYC/SF success story,
Progression to AIDS. official AIDS definition, stages of infection, AIDS and TB
UPDATES
AIDS in Black America (cis women at risk)
transmission in resource poor parts of the world.
PreP works but can be beat, resistance mechanism
HIV specific law
Berlin Patient and others: R5 bone marrow transplant has been tried again
vaccine failure due to gp120 sugar coat and RT being error prone
Broadly neutralizing VS R5 antibodies
BnAbs is in trials
Elite Controllers and Calio cats
Evolved resistance in monkeys (twice!)
Post treatment controllers Beuno Aires patient
sugar daddy, double dummy
95-95-95