Which of the following combination of events are associated with activation of the p-adrenergic receptor pathway?
I. Binding of an antagonist.
II. Binding of an agonist.
III. Ligand-induced membrane spanning conformational changes.
IV. Ligand-induced conformational changes that occur only in extracellular region of the receptor.
V. An increased association between the receptor protein and G protein.
VI. An increased dissociation between the receptor protein and G protein.
VII. Association of multiple subunits to form a trimeric G protein.
VIII. Dissociation of the trimeric G protein.
IX. Conversion of Ga(GDP) to Go (GTP).
X. Conversion of GB(GDP) to GB(GTP).
A. I, III, VI, VIII, & IX
B. II, III, VI, VIII, & IX
C. II, IV, VI, VIII, & IX
D. II, III, VI, VIII, & X
E. II, III, V, VII, & XI