You need to design an antagonistic peptide (or spike protein) that binds to Receptor 2 (R2) but does not bind to Receptor 1 (R1). Based on the chemical properties of the receptor binding sites, which set of three amino acids should be used in the peptide to ensure it selectively binds to R2 while avoiding R1?
Site 1: Val, Site 2: Gly, Site 3: Pyr
Site 1: Can, Site 2: Ile, Site 3: Val
Site 1: Ser, Site 2: Ile, Site 3: His
Site 1: Orn, Site 2: Val, Site 3: Mga
Site 1: Tyr, Site 2: Orn, Site 3: Pyr