3. A cohort study was designed to study the relationship between urine
protein/creatinine (uPCR) and the incidence of kidney replacement therapy (dialysis
or transplant). uPCR was categorized as <0.20, 0.20-<1.00, 1.00-<2.00, and ≥2.00.
The relative risks of receiving kidney replacement therapy among those with uPCR
0.20-<1.00, 1.00-<2.00, or ≥2.00 (compared to those with uPCR < 0.20) were 0.75,
1.25, and 2.50, respectively. Which of the statements below is true? [Hint: You
should draw a figure/table of the level of exposure and relative risks provided to help
you answer this question.]
A. There was a dose-response relationship between uPCR and the incidence of
kidney replacement therapy.
B. There was not a dose-response relationship between uPCR and the
incidence of kidney replacement therapy.
C. The relative risk of kidney replacement therapy comparing those with an
uPCR ≥2.00 to those with an uPCR between 1.00-<2.00 is 1.67.
D. Both A and C
Ε. Both B and C