membrane excitement, firing properties, and spike frequency.
4. You are studying a myelinated axon with the following values. $P_K$=0.95, $K_{in}$=200mM,
$K_{out}$=5mM, $P_{Na}$=0.05, $Na_{in}$=5mM, $Na_{out}$=130mM.
a) The Na+ channels in a node of Ranvier open causing a 30 nS increase in
conductance. What is the total current? [hint: $I = g (V_m - E_{Na})$, S is the unit for
conductance (g).]
b) What is the depolarization caused by this current, if the $R_m$=8 M??
c) What will be the depolarization at the next node if the $R_m$ along the internode is
1M?*cm$^2$ and the $R_i$ is 10M?*cm, and the internode is 0.1cm long?
[hint: $V_x = V_0 e^{x/?}$, $? = \sqrt{R_m/R_i}$]
d) What parameter changes in a demyelinating disease? Why? What will happen to
action potential propagation?