Several small aromatic molecules, such as phenol red, which is used as a nontoxic drug model, have been shown to inhibit the formation of amyloid fibrils in laboratory model systems. A goal of the research on these small aromatic compounds is to find a drug that efficiently inhibits the formation of amyloid in the brain in people with incipient Alzheimer disease.
Why would molecules with aromatic substituents disrupt the formation of amyloid?
O Molecules with aromatic substituents interfere with stacking of aromatic residues within fibrils.
O Molecules with aromatic substituents cause highly unordered fibrils to become more structured.
O Molecules with aromatic substituents prevent $\beta$ sheet formation in amyloid fibrils.
O Molecules with aromatic substituents prevent $\alpha$ helix formation in amyloid fibrils.
