What is one major challenge that multicellular organisms must face which single-celled organisms don't experience?
Multicellular organisms must obtain nutrients from the environment, while single-celled organisms can make their own food.
Many cells inside a multicellular organism do not have access to the outside environment and the whole organism must provide food, oxygen, and a way to get rid of wastes to each of these cells, considerations which single-celled organisms take care of for themselves.
Multicellular organisms must worry about predators, while single-celled organisms are too small to be eaten.
Single-celled organisms must build their bodies through a developmental process which ensures they build consistent structures for interacting with their environment, while multicellular organisms build bodies by simple cell division