Problem 11.22
Many human genes are known to have homologs in the mouse genome. One approach to investigating human hereditary disease is to produce mutations of the mouse homologs of human
genes by methods that can precisely target specific nucleotides for mutation.
Part A
Numerous studies of mutations of the mouse homologs of human genes have yielded valuable information about how gene mutations influence the human disease process. In general
terms, describe how and why creating mutations of the mouse homologs can give information about human hereditary disease processes.
Select the two correct answers.
Mice have a much smaller genome than humans.
Mice are useful for performing experimental manipulations that are not possible in the case of humans.
Mice and human genetic disorders have arisen from conserved and related evolutionary processes.
Mice are also diploids organisms.
