1-EHEHCHEH, why is it wrong? two reason:
2- which one is stable helix?
a) Ala - Leu - Met - Ala
b) Pro - Gly - Pro - Asp
3- which one of the following two sequence alignment its better and why?
(3 marks)
a) Arg Ile Trp Ile Ser
Arg Ile Try Ile Ser
b) Arg Ile Trp Ile Ser
Arg Ile Ser Ile Ser
4-sequence alignment of a protein P has identified three possible templates
in the PDB, on the basis of the data provided in the table below on
sequence similarity, x-ray crystal structure resolution, the percentage of
residue in favoured and disallowed regions in the ramachandran plot
explain which template is the best one to use (4 mark)
template Sequence similarity (%) Resolution A Ramachandra)
1 80 1.8 87/13
2 70 3.0 96/4
3 90 2.0 96/4
5-sequence A - 86 amino acids, sequence B - 267, which alignment is
best?
6- in GLIDE which ligand has strongest binding affinity? interaction that
has the largest contribution? smallest?