The following is a forest plot looking the effect of statins on risk of death and acute coronary syndromes in pre operative patients. Based on the forest plot and associated information we can conclude that overall statins __________.
Death or acute coronary syndrome (cardiac surgery studies)
Dotani et al 2000 w13
1/100 12/210 1.25 0.18 (0.02 to 1.37)
Pan et al 2004 w21
54/343 52/320 12.14 0.97 (0.63 to 1.50)
Ali and Buth 2005 w22
155/3559 117/1913 17.61 0.69 (0.53 to 0.89)
Subtotal (95% CI) 4002 2443 31.00 0.68 (0.42 to 1.11)
Total events: 210 (statin), 181 (no statin)
Test for heterogeneity: ?²=3.74, df=2 (P=0.15), l²=46.6%
Test for overall effect: Z=1.54 (P=0.12)
Total (95% CI) 8779 8487 100.00 0.70 (0.57 to 0.87)
Total events: 588 (statin), 819 (no statin)
Test for heterogeneity: ?²=12.07, df=12 (P=0.44), I²=0.7%
Test for overall effect: Z=3.24 (P=0.001)
0.1 0.2 0.5 1 2 5 10
Favours treatment Favours control
from BMJ 2006;333:1149
- The results are not statistically significant and are inconclusive
- The risk of death is decreased with treatment by 30%
- increase the risk of death by 70%
