Greg and Jennifer, neither of whom have cri du chat, had a baby with cri du chat syndrome. The manifestation of which includes microcephaly (small head), cat-like cry, and intellectual disabilities. This is a dominant condition due to a partial chromosomal deletion on one chromosome 5.
a. What type of genetic analysis (covered in class) could be used to identify this syndrome? Sketch what this individual would look like at chromosome 5 in this analysis.
b. Neither Greg nor Jennifer has cri du chat. How did the child come to have this syndrome?
c. If the chromosome deletion occurred on only one chromosome, is it possible for this child to have an unaffected offspring?
d. The size of the chromosomal deletion will impact the severity of the symptoms of the disorder. Explain why.
