Question 4 (1 point)
Researchers have examined the spread of fluoroquinolone-resistant N. gonorrhoeae
from Asia in the mid-1990s that contained a SNP mutation in the gyrA gene that
codes for the enzyme, DNA gyrase, that is normally blocked by fluoroquinolones
from untangling the knots that form in DNA circles in bacteria during their
duplication. The type of resistance mechanism found in these mutants is an example
of
a modification of metabolic pathways that can circumvent the antibiotic effect.
an active efflux pump that spews antibiotic molecules outside the bacteria
a disruption in the target of the antibiotic
antibiotic-degrading enzymes that chemically degrade or modify the antibiotic so
that it is rendered inactive.
