Apoptosis regulates certain cells by balancing proliferation and cell death, selectively eliminating injured and aged cells, and controlling regeneration. There are 2 apoptotic pathways: extrinsic and intrinsic. Match the processes to the correct pathway.
extracellular signaling proteins, TNF and Fas ligand, trigger apoptosis
death cell receptor independent
death cell receptor dependent
Triggered by DNA damage with activation of p53 protein, ROS, hypoxia, decreased ATP, or cellular senescence
Fas ligand binds to its receptor forming the death-initiating complex by converting procaspase-8 to caspase-8 and activating endonucleases that cause DNA fragmentation
Bcl2 protein regulators insert into the mitochondrial membrane opening channels for protein release into the cytoplasm
mitochondria releases cytochrome c into the cytoplasm resulting in binding to caspase-3 allowing for bridging of the pathways and activation of caspase-8
