As a pharmacist, you are interested in knowing how quickly the kidney clears a
newly developed antibiotic called Z1977. After administering an oral dose of the
drug to a volunteer subject, you sample blood and urine and determine the drug’s
concentrations in each. You also inject the subject with inulin and paraminohippuric
acid (PAH) and, after a period of time, you obtain the following data from blood and
urine analyses:
Plasma Z1977 concentration = 1 mg/mL
Plasma inulin concentration = 10 mg/mL
Plasma PAH concentration = 4 mg/mL
Urine Z1977 concentration = 400 mg/ml
Urine PAH concentration = 900 mg/mL
Urine inulin concentration = 500 mg/mL
Urinary flow rate = 0.5 ml/min
Hematocrit = 40
What is GFR for this subject?
What is the renal clearance rate of Z1977? What does it tell you about how the kidney
handles this drug?
What is renal blood flow?
What is the renal filtration fraction in this subject? What does the value mean?