Question 3 [25 marks]
a) On the diagram provided in the Answer Book, draw a line across each peptide bond
in oligopeptide 3a. Write the single-letter sequence in the space provided. [6 marks]
b) On the diagram provided in the Answer Book, CIRCLE all the chiral centres in
oligopeptide 3a. [4 marks]
c) Complete the Table in the Answer Book to indicate, for oligopeptide 3a, the charges
on ionisable groups and the net overall charge at pH 7 and at pH 11. [4 marks]
d) What moieties within oligopeptide 3a are those mainly responsible for the formation
of an alpha-helix? Name the process that leads to the unfolding of the alpha helix to
yield a random coil. [3 marks]
e) Complete the Table in the Answer Book to indicate, for oligopeptide 3a, which amino
acid side chains will be involved in: hydrophilic interactions, hydrophobic
interactions, disulphide bridges and salt bridges. In each case, briefly justify your
choice. [8 marks]
3a
NH?
H?N
SH
0
NH
NH
NH
OH
H?N
NH
NH
NH
OH
HO