I. You are infected with TB bacteria. The infection is in the lung. Describe the role of physical,
innate and adaptive immune responses of a primary immune response to this pathogen in
the lungs. Evaluate the role of TNF-a, CCL2 & IFN-y in your response. Name the type(s) of
effector T cell(s) that are important in this response. Discuss the location and production of
TB-specific memory B cells and plasma cells in germinal centers. Describe the location and
mechanisms by which lymphocyte activation, proliferation and differentiation occur &
summarize all three phases of the immune response. Name and describe the function of
signals, receptors, chemokine, cytokines, antibodies, MHC class I and/or MHC class II
pathways. Any mention of inflammation needs to include details related to factors
promoting inflammation and details concerning the steps of inflammation as well as cell
types involved.
