E. Complete the following sentence about regulation of cell division.
MPF (maturation promoting factor) is formed by a combination of \_\_\_\_\_\_\_\_ and \_\_\_\_\_\_\_\_. When MPF is formed, it phosphorylates \_\_\_\_\_\_\_\_ that degrades cyclin and when cyclin level goes down, MPF activity \_\_\_\_\_\_\_\_. When cyclin levels go up, \_\_\_\_\_\_\_\_ activity increases and cell division starts.