2.2.3. Genetically heterogenous malignancies remain a clinical challenge to treat and cure largely because:
a. The have one driver mutation
b. They are composed of 1-3 subclones, each with a different driver mutation
c. They exhibit whole genome doubling
d. They have many subclones, each containing varying mutagenic and immunogenic features
e. They have a high proportion of Chromothripsis.
2.2.4. Micronuclei
a. Induce senescence
b. Exist outside the nucleus
c. Induce chromosomal instability
d all of the above