Please answer the following
to para products.
R
HNO3 H2SO4
NO.
NO2 meta < 2% <2% <2% <2% <2%
para 32% 38% 53% 85% 96%
ortho 66% 60% 45% 13% <2%
R=
H
Methyl Ethyl Isopropyl Tert-butyl
means there should be a 2:1 preference of ortho vs para products for the second substitution. Memorization Task: Any ortho/para directing groups that are larger than methyl will favor para substitution. NH2, CH3, OH are considered small groups. CI, Br and hydrocarbons bigger than methyl are considered large 1) What percentages of ortho to para should there be for a 2:1preference? a.Is this consistent with the results of nitration of benzene? 2)As the R group gets larger, the hindrance increases,and there is a higher% of the product and a lower percentage of the product. 3) Which R group is large enough to shift the ratio of ortho/para, so that ortho is no longer the major product?