The R1 subunit of ribonucleotide reductase contains two allosteric sites, one that regulates the overall enzyme activity and another that regulates the substrate specificity of the enzyme.
Select the molecules that bind the site regulating overall ribonucleotide reductase activity.
$\square$ dATP
$\square$ GTP
$\square$ ATP
$\square$ dGTP
Classify the nucleotides that affect the activity of ribonucleotide reductase based on their allosteric effects. Not all of the nucleotides will be placed.
Stimulates overall activity
Inhibits overall activity
Changes substrate specificity
Answer Bank
dATP
ATP
dCTP
TTP
dATP and ATP
dGTP
GTP