The clearance (Cl) using the K and V values in {(:m(L)/(m)in)}\nThe HEALTHE NL Ed...\nprescribing docume.\nInfort\nThe volume of distribution using the AUC (trapezoidal) method ( V_(AUC) in (L)/(k)g )\nThe fraction of the dose remaining in the body at time 9.2hr (Fraction)\nThe plasma concentration of kinetolol at time in {(:m(g)/(L))}\nThe time for the plasma concentration to reach 4.58m(g)/(L)(T_(1)inhr)\nThe time for the fraction of the dose in the body to reach 0.873(T_(2)inhr)\nThe elimination rate of the drug at time 3.4hr when the plasma concentration is 12.5m(g)/(L) (dAe/dt in m(g)/(h)r )\nA new dose if a C_(0) of 58m(g)/(L) is desired (Dose in _(1)mg )\nA new dose if a duration of effect of 27hr is desired, assuming a minimum effective concentration of 8.3m(g)/(L) (Dose 2inmg )\nIn another patient, 13.2% of an iv bolus dose remains in the body at 105hr following the drug injection. What is the half life of the drug in this new patient\nII. Please use equations only (no graph or linear regression analysis) to estimate the following kinetic parameters assuming that only two plasma concentrat hr(12.5m(g)/(L)) and at 27hr(5.71m(g)/(L)). Also be prepared to discuss in class the differences between the kinetic parameters obtained for this patient in secti\nThe plasma half life in {(:hr)}\nThe plasma concentration immediately after the drug injection in {(:m(g)/(L))}\nThe volume of distribution ( V in (L)/(k)g )\nThe clearance ( Cl in m(L)/(m)in\n\\table[[,,,Answers:,],[I. 1. C_(0)(m(g)/(L)),2. V V_(EXT )((L)/(k)g),3. K(hr^(-1)),4. t_((1)/(2))(hr),5. AUC_(TRAP ) (mg.hr/L),6. AUC_(COMP )
learance (Cl) using the K and V values (Clgy in mL/min)
prescnbing docume Info
9.The volume of distribution using the AUC (trapezoidal)method (VAUc in L/kg) 10.The fraction of the dose remaining in the body at time 9.2 hr (Fraction 11.The plasma concentration of kinetolol at time 9.2 hr (CEst in mg/L) 12.The time for the plasma concentration to reach 4.58 mg/L(T in hr) 13.The time for the fraction of the dose in the body to reach 0.873 (T in hr) 14.The elimination rate of the drug at time 3.4 hr when the plasma concentration is 12.5 mg/L(dAe/dt in mg/hr) 15.A new dose if a Co of 58 mg/L is desired Dose in mg 16.A new dose if a duration of effect of 27 hr is desired,assuming a minimum effective concentration of 8.3 mg/LDose in mg 17.In another patient, 13.2% of an iv bolus dose remains in the body at 105 hr following the drug injection.What is the half life of the drug in this new patien II.Please use equations only (no graph or linear regression analysis to estimate the following kinetic parameters assuming that only two plasma concentrat hr (12.5 mg/Land at 27 hr 5.71 mg/L.Also be prepared to discuss in class the differences between the kinetic parameters obtained for this patient in secti 18.The plasma half life t1/2 in hr) 19.The plasma concentration immediately after the drug injection (Co in mg/L)
20.The volume of distribution (V in L/kg
21.The clearance (Cl in mL/min)
Answers: 5.AUCTRAp(mg.hr/L) 6.AUCcOMP 19.6 431 422 13.Thr 14.dAe/dt 33.4 3.85 7.41 20.VL/kg 21. CI (mL/min) .236 9.92
2.VEXTL/kg 221
3.Khr .0353 11.CESTmg/L 10.8 19.Co mg/L 14
L.1.Cmg/L) 14.9 9.VAUcL/kg .217 17.t1/2hr 36
10.Fraction .723 II.18.12hr 20.9
Linear Graph
Semilog Graph
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